Bone Marrow Products
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Bone Marrow is the birth place of the human immune system. A wide array of cell progenitors are found withing the marrow and help researchers identify the causes of blood and autoimmune diseases. At Conversant Bio, we carry a variety of bone marrow samples obtained from both normal and diseased patients. The bone marrow cells can be purified to Bone Marrow Mononuclear Cells (BMMCs) or sold as a prospective fresh collection. To learn more about our current bone marrow inventory or inquire about your specific needs, please click on the links below. We are here to help you obtain the ideal biospecimens you need for your research. Because Patients Are Waiting… |
| Bone Marrow is the soft, flexible tissue found in the interior of bones. It is responsible for new blood cell production and is a critical component of the lymphatic system as a primary producer of lymphocytes. There are 2 types of bone marrow: red marrow, which consists mainly of hematopoietic tissue, and yellow marrow, consisting mainly of fat cells. The three primary components of blood (red blood cells, white blood cells, and platelets) are produced from red marrow. At birth, all bone marrow starts as red marrow but as the human body ages some of this red marrow turns into yellow marrow. Red marrow can be found in a variety of locations human bones including the hip, breast, ribs, cranium, and vertebrae. Additionally, this marrow is found in the cancellous material at the epiphyseal ends of long bones (i.e, the femur and humerus). Yellow Marrow is found in the medullary cavity – the hollow interior of long bones. |
bone marrow product types
bone marrow | B Cells, CD19These B-cells are obtained through positive selection involving antibody binding of cell-surface CD19 and magnetic column-based isolation. This results in CD19+ B-cells that are >90% pure by flow cytometry.key applications:
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bone marrow | B Cells, Negative SelectionThese B-cells are obtained through negative selection involving binding of non-B-cells and magnetic column-based isolation. This results in B-cells without antibodies bound to their cell surface ("untouched") that are >90% pure by flow cytometry.key applications:
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bone marrow | T-Cells, CD3These T-cells are obtained through positive selection involving antibody binding of cell-surface CD3 and magnetic column-based isolation. This results in CD3+ T-cells that are >90% pure by flow cytometry.key applications:
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bone marrow | T-Cells, Negative SelectionThese T-cells are obtained through negative selection involving binding of non-T-cells and magnetic column-based isolation. This results in T-cells without antibodies bound to their cell surface ("untouched") that are >90% pure by flow cytometry.key applications:
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bone marrow | CD45These hematopoietic cells are obtained through positive selection involving antibody binding of cell-surface CD45 and magnetic column-based isolation. This results in CD45+ hematopoietic cells that are >90% pure by flow cytometry.key applications:
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bone marrow | mononuclear cellsMononuclear cells, mainly consisting of monocytes and lymphocytes, are obtained by gradient centrifugation using Ficoll. These cells are aliquoted and cryopreserved at -150C in a manner that maintains post-thaw cellular viability.key applications:
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bone marrow | fresh samplesFresh bone marrow, shipped the same day of draw for overnight delivery, is available from various donors / patients. Because we obtain samples directly from patients and donors for overnight delivery please contact us to discuss your specific needs. We will work with you to obtain the exact specimens you need for your research.key applications:
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bone marrow | viable plated cellsCells, fresh or previously cryopreserved, can be plated on any desired plates or flasks and then shipped the same day for overnight delivery. Plates containing cells are heat-sealed prior to shipping to minimize leakage between wells. This option is ideal for researchers wanting to place cells in their desired assay conditions as quickly as possible or when concerned with properly thawing cryopreserved primary samples.key applications:
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bone marrow | buffy coatMononuclear cells, mainly consisting of monocytes and lymphocytes, are obtained by gradient centrifugation using Ficoll. These cells are aliquoted and frozen at -80C in a manner that does not maintain post-thaw cellular viability.key applications:
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bone marrow | special processingBone marrow can be processed in a manner that best suites your research. Please provide us with a detailed description of how you will like the sample handled. To inquire about our special processing services please click the icon to the right and you will be directed to our contact page. There you will be able to fill out a form and describe the specific samples you are seeking. |
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