Rheumatoid arthritis is marked by chronic inflammation of many tissues, but predominately affects the flexible (synovial) joints. Patients suffering from rheumatoid arthritis experience two seasons, flare-up and remission. During the flare-up season, a patient may experience elevated symptoms. During the remission season, a patient may be asymptomatic. A Complete Guide: Rheumatoid Arthritis, goes into depth about diagnosis, biomarkers, and other necessities for researchers searching for a cure.