10 Ways Adult Stem Cells Advance Tissue Regeneration Studies

Posted by Luke Doiron on Jan 27, 2015 6:00:00 AM


The adult stem cell is a cell that can be found among specialized, more differentiated cells in a tissue or organ. They have 2 unique features:

  1. Self Renewal (ability to propagate)

  2. Multilineage differentiation or Multipotency (ability to develop into all major tissue types)

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Beyond the Basics: 14 Components of Normal Bone Marrow You Might Have Missed

Posted by Luke Doiron on Jan 20, 2015 6:00:00 AM


The normal bone marrow is the sole site of effective hematopoiesis in humans, and occurs in the soft, spongy, gelatinous tissue found in the hollow spaces in the interior of bones. The average weight of this tissue is about 4% of the total body weight, or 2.6 kg in an adult weighing 65 kg. It consists of stem cells, which are large, "primitive," undifferentiated cells supported by fibrous tissue called stroma.

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6 Challenges to Using Adult Stem Cells in Hematology Research

Posted by Luke Doiron on Jan 13, 2015 6:00:00 AM

Adult stem cells can be generated from a variety of organs, ranging from the brain’s neural cells, to the skin. The most accessible stem cells and progenitor cells however, are found in bone marrow, which is rich with these cells. This type of “therapy” has potential; benefit for a variety of diseases, including many neurological diseases, such as strokes, spinal-cord injury, Alzheimer’s disease, Parkinson’s disease, and Lou Gehrig’s disease.

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3 Key Benefits of Bone Marrow Mononuclear Cells

Posted by Luke Doiron on Jan 6, 2015 6:00:00 AM


Human bone marrow mononuclear cells (BMMCs) are isolated from whole bone marrow, and contain a diverse cell population, including lymphocytes, monocytes, mesenchymal stem cells and hematopoietic progenitor cells. BMMCs are invaluable for researchers studying the genetic and molecular basis for diseases.

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The Many Uses of Normal Bone Marrow Tissue

Posted by Luke Doiron on Dec 30, 2014 6:00:00 AM


In a healthy individual, the bone marrow space is largely occupied by hematopoietic cells and adipocytes, whereas the stromal cells and extracellular matrix claim a very small space. Maturation of hematopoietic cells is a complex, but orderly process that takes place in the bone marrow “microenvironment.” This involves cell-to-cell interaction, specific growth hormones and various proteins called cytokines. The unique niche of the bone marrow microenvironment makes for a rich source of tissue for scientists to perform important research.

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10 Unexpected Uses for Adult Stem Cells

Posted by Luke Doiron on Dec 23, 2014 6:00:00 AM

Adult pluripotent stem cells have the advantage of avoiding ethical issues associated with the use of human fetal cells or embryonic cells. According to a recent article published in the Encyclopedia of Molecular Cell Biology and Molecular Medicine, adult autologous pluripotent stem cells can be used for transplants that avoid tissue rejection making transplantation possible without the use of immunosuppressive drugs, which are not without their own side effects. This rapidly progressing field within regenerative medicine has the potential to revolutionize the treatment of genetic and somatic human diseases. By selectively targeting diseased tissue (such as beta cells of the pancreas), and replacing them with genetically programmed stem cells, there is hope for the damaged cells to regenerate.

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Red Bone Marrow vs. Yellow Bone Marrow: What is the Difference

Posted by Luke Doiron on Dec 16, 2014 6:00:00 AM


Bone marrow (also known as myeloid tissue) is a red, soft, semi-solid, gelatinous tissue, which is found in the axial skeleton. It is highly vascular and enriched with many blood vessels and capillaries. Deep within the bone marrow resides a type of cell known as mesenchymal stem cells (MSCs). These immature cells can differentiate into cells that produce bone, cartilage, fat, or muscle. Researchers are also able to identify a wide range of cell progenitors that are found within the bone marrow, which, in turn, helps them understand and identify causes of blood and autoimmune diseases. Consequently, access to normal bone marrow is crucial to the advancements in clinical research, and treatment of disease.

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5 Uses of Normal Bone Marrow in Biomarker Identification and Validation

Posted by Luke Doiron on Dec 9, 2014 6:00:00 AM


The National Institute of Health (NIH) defines a biomarker as, “a characteristic that is objectively measured and evaluated as an indication of normal biologic processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention.” Many researchers rely on biomarkers to help them understand the ways in which cells act, based on the protein markers found on the cell surface.

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