What Diseases Tissue Microarrays Can Be Used For

Posted by Luke Doiron on Sep 22, 2016 10:00:00 AM

    

The future belongs to those who believe in the beauty of their dreams, said Eleanor Roosevelt, First Lady of the United States, 1932-1944. The science of the molecular biology of the gene is now more than 60 years old and in fact, the new goals and new dreams are just beginning.

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Recent Publications That Utilize Cell-Free DNA

Posted by Luke Doiron on Sep 20, 2016 2:00:00 PM

    

When cells die, they leave behind tiny amounts of highly fragmented DNA that circulate in plasma. This cell-free DNA (cfDNA) contains the evidence about disease processes and physiological conditions affecting tissues throughout the body. Consequently, cfDNA provides a non-invasive “liquid biopsy” and a promising biomarker for cancer and other diseases.

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Preparation Procedures for Tissue Microarrays

Posted by Luke Doiron on Sep 15, 2016 9:00:00 AM

    

“One for all and all for one; that is our device,” wrote Alexandre Dumas over a hundred years ago in the famous novel, The Three Musketeers. The devotion to working together and teamwork is equally as critical in the present and bright future of new genomics technologies such as tissue microarray (TMA) devices.

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Best Practices for Handling, Storing, and Using Streck Tubes

Posted by Luke Doiron on Sep 13, 2016 9:32:00 AM

    

The integrity of blood samples is crucial for the most accurate analysis of cell-free DNA (cfDNA). Using the proper equipment for collecting, processing, storing and shipping whole blood samples will ensure the highest quality cfDNA is maintained and the most reliable results are obtained.

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Bioinformatics Analysis of cfDNA Sequencing Data

Posted by Luke Doiron on Sep 8, 2016 9:30:00 AM

    

Circulating, cell-free DNA (cfDNA) is currently being utilized for a variety of non-invasive tests, including liquid biopsy for lung cancer patients (a practice that was just approved by FDA in June 2016).

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Recent Immunohistochemical Studies Using Human Tissue Samples

Posted by Luke Doiron on Sep 6, 2016 2:00:00 PM

    

First developed for commercial use in the 1990s, laser-based tissue microdissection is a critical tool for the molecular analysis of histological sections.

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Creating Targeted Next-Gen Sequencing Panels from FFPE Samples

Posted by Luke Doiron on Aug 30, 2016 8:00:00 AM

    

Next Generation Sequencing (NGS) technologies yield a fast-forward from the completion of the Human Genome Project (1990-2003) with the laborious, slow Sanger methods described in the late 1970s to the precision medicine trending now. NGS users, like the fictional characters in Star Trek: The Next Generation, can “boldly go where no one has gone before.” In the same way, people who use NGS methods currently can sequence one person’s genome in its entirety in just one day.

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Changes in Peripheral Blood Over a Person's Lifetime

Posted by Luke Doiron on Aug 25, 2016 8:00:00 AM

    

 

Investigating the composition of peripheral blood of an individual can provide a window for both innate and outside experiences. While genetics will certainly influence composition, experiences like stress, disease, smoking and infection will also have an impact. Researchers studying cells isolated from peripheral blood donors need to be aware of the diverse influences that can affect their baseline. Some examples of these are outlined below.

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