5 Key Summaries from the AACR Molecular Cancer Research RAS Collection

Posted by Luke Doiron on Oct 6, 2015 8:00:00 AM

Here we summarize five recently published articles from Molecular Cancer Research, a publication of the American Association for Cancer Research, focusing on its RAS research collection.

Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations

KRAS mutations, the most common genetic abnormalities found to date in cancer, vary depending upon the type of cancer and the specific area of mutation. This in turn impacts therapeutic efficacy. In this study, authors analyzed the unique biochemical properties of different KRAS mutations, and postulate that such biochemical profiling linked to classification of KRAS-driven cancers may enhance the selection of appropriate therapies.

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The Benefits of Using Patient Derived CRC Primary Cultures for Research

Posted by Luke Doiron on Sep 29, 2015 9:00:00 AM


It can cost up to $4 billion and take, on average, 12 years to bring a new drug to market. One of the biggest challenges for R&D is improving the early clinical discovery steps, so that better potential candidate molecules make it into human clinical trials. It’s increasingly recognized that one of the main reasons for the large number of drug failures is the use of models that are not predictive or are irrelevant to understanding critical disease mechanisms.

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The Impact of Storage Times on FFPE Colorectal Cancer Tissues

Posted by Luke Doiron on Sep 22, 2015 9:00:00 AM

Advancements in molecular analysis and pathology methods have been striking over the past decade, and one reason is the discovery that archival formalin-fixed paraffin-embedded (FFPE) tissue specimens can serve as good sources for a variety of molecular-based studies. While it was once believed that the formalin fixation process permanently rendered unusable the proteins that become cross-linked during fixation, now researchers are able to extract and amplify key proteins and biomarkers from the huge reservoir of FFPE archival samples, and so advance their understanding of cancer and other major diseases.

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The Many Metastatic CRC Models to Use for Research

Posted by Luke Doiron on Sep 15, 2015 12:08:00 PM

Colorectal cancer (CRC) is the third most common cancer worldwide and in the U.S. Because it is increasing in incidence and is often diagnosed late, there is great urgency for good models to study CRC and to identify diagnostic tools and effective drug therapies. One of the most important tools is the cellular or animal model, both of which help in pre-clinical investigation of novel compounds, toxicity, sensitivity and resistance research. Over the past years, a wide range of models have been developed and tested for reliable predictive value in human clinical studies.

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5 Problems Associated with FFPE Nucleic Acid Isolation

Posted by Luke Doiron on Sep 8, 2015 10:19:05 AM

By some estimates, there are more than one billion formalin-fixed paraffin embedded (FFPE) tissue specimens preserved in tissue archives around the world. These specimens are invaluable resources for histopathology analysis and, more recently, for molecular analysis of the nucleic acid materials contained in these samples. Recovery of nucleic acids from FFPE samples is now possible with newer lab isolation technologies, helping researchers to unlock genetic information that can answer questions related to the molecular basis of cancer and other diseases, aid in drug discovery, and gain a better understanding of the response to specific therapeutic modalities.

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The 5 Qualities of Superior FFPE Suppliers

Posted by Luke Doiron on Sep 1, 2015 10:18:36 AM

You have many choices in suppliers when you're seeking FFPE specimens for your research. As with most purchasing decisions, it's a fact that not all FFPE suppliers are the same when it comes to providing the right kind of FFPE specimens needed to move your project forward. Here are 5 key factors that ensure your FFPE supplier is dedicated to providing superior specimens:

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Quick Turn-Around with Conversant Bio Partnership: A Case Study

Posted by Luke Doiron on Aug 29, 2015 4:30:00 PM


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What Method Can Be Used to Create a Cancer Cell and PBMC Coculture?

Posted by Luke Doiron on Aug 27, 2015 10:46:00 AM

Recent findings from the cancer research community have identified the importance of cell-cell communications in the activation or inhibition of tumor development. Cellular co-cultures have become an important in-vitro methodology for gaining a better understanding of how cells interact in the cancer microenvironment. These insights are also fueling development of drug modulators that effectively target the cell-to-cell dialogue that may fuel cancer development or therapy resistance.

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