Improving Personalized Medicine in Oncology Research with Biomarkers

Posted by Luke Doiron on Mar 3, 2015 7:37:51 AM

Major investments in basic science have created an opportunity for significant progress in clinical medicine. Researchers have discovered hundreds of genes that harbor variations contributing to human illness, identified genetic variability in patients' responses to dozens of treatments, and begun to target the molecular causes of some diseases. In addition, scientists are developing and using diagnostic tests based on genetics or other molecular mechanisms to better predict patients' responses to targeted therapy.(1)

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The Role of Surrogate Endpoint Biomarkers in Oncology Research

Posted by Luke Doiron on Feb 24, 2015 9:37:56 AM

Biomarkers and surrogate endpoints have an increasingly important role in both cancer research and clinical practice. Biomarkers can be used to assess prognosis and to predict how individual patients will respond to specific treatments, whereas surrogate endpoints potentially enable the effectiveness of new interventions to be assessed more rapidly, and at times with greater accuracy, than classic endpoints (such as survival) in clinical trials. (1)

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Back to Basics: How Biomarkers are Used in Oncology Research

Posted by Luke Doiron on Feb 17, 2015 11:09:00 AM

A biomarker is defined as a quantifiable indicator of a biological, pathological, or therapeutic response process occurring in the human body. It is found in blood, other body fluids and tissues and is particularly helpful for researchers to understand the normal and abnormal processes. Oncology research in particular, focuses on identifying and measuring certain protein and molecular expressions that are associated with neoplasia.

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3 Advancements in Drug Development for Oncology Research

Posted by Luke Doiron on Feb 10, 2015 7:00:00 AM

Today, we know a wealth of information about cancer that we didn’t know even 20 years ago. Cancer is now seen as a disease of individual cells with its own molecular circuitry. By determining defects at the molecular level, it becomes possible to intuit and predict how cancer cells will behave, and assign biological properties to understand implications for disease.

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How To Prepare Adult Stem Cells for CD34+ and CD 138+ Isolation

Posted by Luke Doiron on Feb 3, 2015 6:00:00 AM

 

In recent years, large bodies of research indicate multilineage differentiation potential and immunomodulatory properties of human mesenchymal stem cells (MSCs). Furthermore, the potential applications in the treatment of degenerative and immunologic diseases are promising, and offer a powerful therapeutic tool in the arsenal against many physical conditions. The number of clinical trials in this area is steadily increasing, and the need for bioavailability of MSCs is all the more important.

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10 Ways Adult Stem Cells Advance Tissue Regeneration Studies

Posted by Luke Doiron on Jan 27, 2015 6:00:00 AM

 

The adult stem cell is a cell that can be found among specialized, more differentiated cells in a tissue or organ. They have 2 unique features:

  1. Self Renewal (ability to propagate)

  2. Multilineage differentiation or Multipotency (ability to develop into all major tissue types)

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Beyond the Basics: 14 Components of Normal Bone Marrow You Might Have Missed

Posted by Luke Doiron on Jan 20, 2015 6:00:00 AM

 

The normal bone marrow is the sole site of effective hematopoiesis in humans, and occurs in the soft, spongy, gelatinous tissue found in the hollow spaces in the interior of bones. The average weight of this tissue is about 4% of the total body weight, or 2.6 kg in an adult weighing 65 kg. It consists of stem cells, which are large, "primitive," undifferentiated cells supported by fibrous tissue called stroma.

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6 Challenges to Using Adult Stem Cells in Hematology Research

Posted by Luke Doiron on Jan 13, 2015 6:00:00 AM

Adult stem cells can be generated from a variety of organs, ranging from the brain’s neural cells, to the skin. The most accessible stem cells and progenitor cells however, are found in bone marrow, which is rich with these cells. This type of “therapy” has potential; benefit for a variety of diseases, including many neurological diseases, such as strokes, spinal-cord injury, Alzheimer’s disease, Parkinson’s disease, and Lou Gehrig’s disease.

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