Immunology is the study of how organisms defend the body from invading microorganisms.
Significant advances in the field include the identification of the two arms of immune responses known as 'innate' and 'adaptive.' Initially, innate immunity was considered to be a relatively nonspecific and simple part of the overall immune response, while adaptive immunity was believed to provide antigen-specific protection from microbial and viral infection. (1)
Researchers are interested in the inner workings of the immune system, particularly peripheral blood mononuclear cells (PBMCs), which include white blood cells, that are key responders to infection. They found a whole host of genes in these cells which varied in their transcription. Assessing gene expression profiles from readily available tissues, such as peripheral blood, would be useful and desirable in clinical practice. Importantly, the conversion of blood gene expression data into practical diagnostics could be a turning point in molecular medicine and personalized genomics. (2)Read More