Ways that PBMC Isolation Aids Immunology Research Challenges

Posted by Luke Doiron on Mar 24, 2015 10:46:00 AM

Immunology is the study of how organisms defend the body from invading microorganisms.

Significant advances in the field include the identification of the two arms of immune responses known as 'innate' and 'adaptive.' Initially, innate immunity was considered to be a relatively nonspecific and simple part of the overall immune response, while adaptive immunity was believed to provide antigen-specific protection from microbial and viral infection. (1)

Researchers are interested in the inner workings of the immune system, particularly peripheral blood mononuclear cells (PBMCs), which include white blood cells, that are key responders to infection. They found a whole host of genes in these cells which varied in their transcription. Assessing gene expression profiles from readily available tissues, such as peripheral blood, would be useful and desirable in clinical practice. Importantly, the conversion of blood gene expression data into practical diagnostics could be a turning point in molecular medicine and personalized genomics. (2) 

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3 Types of Immune Cells in Human Peripheral Blood Mononuclear Cells (PBMCs)

Posted by Luke Doiron on Mar 17, 2015 9:58:00 AM

 

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A History of Cancer Research: 7 Crucial Breakthroughs

Posted by Luke Doiron on Mar 12, 2015 2:34:00 PM

The advancements in cancer drug discovery have really exploded in the last decade, but there have been specific crucial  scientific breakthroughs that have changed the course of targeted cancer therapy and personalized medicine. The field of oncology is burgeoning and current research is addressing specific “tumors” instead of specific “cancers.” For instance, breast cancer is not just one type of cancer. There are 6 known types of breast cancers. The discovery of genetic mutations and biological influences of various tumors, sets the stage for a new field of clinical research in the area of targeted cancer therapy. This paradigm shift is due largely to the following discoveries:

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3 Mistakes You Don't Know You're Making When Sourcing Biospecimens

Posted by Rebecca Parker on Mar 10, 2015 9:13:00 AM

Does this sound familiar?  You’ve just left a planning meeting, and you’ve been tasked with finding the human biospecimens that your team will need to carry out the project. Great you think! If you don’t have a current supplier, figuring out which one to use is the first hurdle. When you do have one, it can still be a challenge to get the samples your team needs. Often you don’t know why it takes so long to find out if the specimens you’re looking for are even attainable.  

Here are 3 mistakes to avoid when sourcing human biospecimens that will make procuring the samples you need easier.

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Improving Personalized Medicine in Oncology Research with Biomarkers

Posted by Luke Doiron on Mar 3, 2015 7:37:51 AM

Major investments in basic science have created an opportunity for significant progress in clinical medicine. Researchers have discovered hundreds of genes that harbor variations contributing to human illness, identified genetic variability in patients' responses to dozens of treatments, and begun to target the molecular causes of some diseases. In addition, scientists are developing and using diagnostic tests based on genetics or other molecular mechanisms to better predict patients' responses to targeted therapy.(1)

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The Role of Surrogate Endpoint Biomarkers in Oncology Research

Posted by Luke Doiron on Feb 24, 2015 9:37:56 AM

Biomarkers and surrogate endpoints have an increasingly important role in both cancer research and clinical practice. Biomarkers can be used to assess prognosis and to predict how individual patients will respond to specific treatments, whereas surrogate endpoints potentially enable the effectiveness of new interventions to be assessed more rapidly, and at times with greater accuracy, than classic endpoints (such as survival) in clinical trials. (1)

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Back to Basics: How Biomarkers are Used in Oncology Research

Posted by Luke Doiron on Feb 17, 2015 11:09:00 AM

A biomarker is defined as a quantifiable indicator of a biological, pathological, or therapeutic response process occurring in the human body. It is found in blood, other body fluids and tissues and is particularly helpful for researchers to understand the normal and abnormal processes. Oncology research in particular, focuses on identifying and measuring certain protein and molecular expressions that are associated with neoplasia.

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3 Advancements in Drug Development for Oncology Research

Posted by Luke Doiron on Feb 10, 2015 7:00:00 AM

Today, we know a wealth of information about cancer that we didn’t know even 20 years ago. Cancer is now seen as a disease of individual cells with its own molecular circuitry. By determining defects at the molecular level, it becomes possible to intuit and predict how cancer cells will behave, and assign biological properties to understand implications for disease.

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